How should I approach rhythm control in a patient with atrial fibrillation who is symptomatic despite rate control?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025Updated: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Consider pharmacological and/or electrical rhythm control for people with atrial fibrillation whose symptoms continue after heart rate has been controlled or for whom a rate‑control strategy has not been successful .

Assess the need for drug treatment for long‑term rhythm control, taking into account the person's preferences, associated comorbidities, risks of treatment and likelihood of recurrence of atrial fibrillation .

If drug treatment for long‑term rhythm control is needed, consider antiarrhythmic drugs such as amiodarone, especially in cases where other treatments are unsuitable or not tolerated .

Discuss the risks and benefits of antiarrhythmic drug therapy with the person, including options like radiofrequency ablation or cryoballoon ablation if drug treatment is unsuccessful or not tolerated .

Consider left atrial ablation if drug treatment is unsuccessful, unsuitable, or not tolerated, and discuss the risks, benefits, and the possibility that symptoms may not be long-lasting .

Educational content only. Always verify information and use clinical judgement.