What are the indications for systemic treatments in patients with severe atopic eczema?

Guideline-aligned answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 14 August 2025 Guideline-Aligned (High Confidence) Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Consider systemic treatments for severe atopic eczema when other management options have failed or are inappropriate, and there is a significant negative impact on quality of life .

Only use phototherapy and systemic treatments under specialist dermatological supervision by staff who are experienced in working with children .

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