What are the first-line topical treatments for mild to moderate acne vulgaris in adolescents?

Offer a 12-week course of one of the following first-line topical treatments for mild to moderate acne in adolescents:

• A fixed combination of topical adapalene with topical benzoyl peroxide, applied once daily in the evening ¹.
• A fixed combination of topical tretinoin with topical clindamycin, applied once daily in the evening ¹.
• A fixed combination of topical benzoyl peroxide with topical clindamycin, applied once daily in the evening ¹.

Consider topical benzoyl peroxide as monotherapy as an alternative if these options are contraindicated or the person wishes to avoid using a topical retinoid or an antibiotic ².