Herpes zoster management in primary care: antiviral indications?

Clinical answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 11 August 2025Updated: 11 August 2025 Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

In primary care, antiviral treatment for herpes zoster is indicated for:

  • People who are immunocompromised, with consideration for clinical judgment regarding the severity of immunosuppression, rash localization, eye involvement, systemic illness, and ability for close follow-up. Severely immunocompromised individuals should be referred for intravenous aciclovir.
  • People aged 50 years and over.
  • People with non-truncal involvement, excluding the head and neck, which warrant admission or specialist advice.
  • People experiencing moderate to severe pain or a moderate to severe rash.
  • People with predisposing skin conditions.
  • Antiviral treatment can be considered for individuals under 50 years with shingles affecting the extremities or trunk, based on clinical judgment.
  • Treatment can be initiated up to one week after rash onset if not possible within 72 hours, particularly for those at higher risk of severe disease or complications.
  • Antiviral treatment is not recommended for immunocompetent children.
  • For pregnant or breastfeeding women with shingles, specialist advice should be sought before prescribing antiviral treatment.

Educational content only. Always verify information and use clinical judgement.