Smoking cessation strategies in primary care, including pharmacotherapy?

Clinical answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 11 August 2025Updated: 11 August 2025 Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

Smoking cessation strategies in primary care include:

  • Offering advice and support to all people who smoke to stop, including referral to local NHS stop smoking services or providing information on how to access these services .
  • Encouraging people who are more dependent on nicotine to attend smoking cessation services, as they may need higher support, medication doses, and multiple attempts .
  • Providing evidence-based interventions such as behavioral support (individual and group), advice on stop smoking treatments (NRT, cytisinicline, varenicline, bupropion), and e-cigarettes .
  • Using behavioral support techniques like individual counseling, group counseling, and adjunctive counseling by health professionals to increase cessation rates .
  • Follow-up visits with repeat support to improve long-term abstinence, especially in the first few weeks after quitting .
  • Monitoring CO levels as a motivational behavioral support technique .

Pharmacotherapy options in primary care include:

  • Nicotine Replacement Therapy (NRT), varenicline, and bupropion, which are effective and more successful than placebo at maintaining abstinence for at least 6 months .
  • Offering NRT, including patches, lozenges, mouth sprays, and combination NRT (patch plus short-acting forms), tailored to individual preferences and nicotine dependence levels .
  • Starting NRT on the quit date, with sufficient supply for at least 2 weeks after the quit date .
  • Providing behavioral support alongside pharmacotherapy to increase success rates .

Educational content only. Always verify information and use clinical judgement.