first line mx depression

Clinical answer with reasoning, red flags and references. Clinically reviewed by Dr Kola Tytler MBBS CertHE MBA MRCGP.

Posted: 10 August 2025Updated: 10 August 2025 Clinically Reviewed
Dr Kola Tytler MBBS CertHE MBA MRCGPClinical Lead • iatroX

The first-line management for depression, if the person wishes to start treatment, is to offer a selective serotonin reuptake inhibitor (SSRI) or serotonin noradrenaline reuptake inhibitor (SNRI) .

For people with less severe depression who do not want treatment, active monitoring with the option to consider treatment later is recommended .

Psychological interventions such as cognitive behavioural therapy (CBT), group exercise, group mindfulness and meditation, and counselling are also considered first-line options depending on the person's preferences and clinical needs .

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