A 55-year-old woman presents with pruritus, steatorrhoea, and osteopenia. AMA is positive at 1:320. ALP is 420 IU/L. She is diagnosed with PBC. What i...

Question

A 55-year-old woman presents with pruritus, steatorrhoea, and osteopenia. AMA is positive at 1:320. ALP is 420 IU/L. She is diagnosed with PBC. What is the mechanism by which UDCA improves cholestasis?

Accepted Answer

Stimulation of hepatocyte secretory capacity and choleresis through displacing toxic hydrophobic bile acids

Answer

Increasing enterohepatic bile acid circulation

Answer

Dissolution of gallstones

Answer

Direct immunosuppression of biliary inflammation

Answer

Inhibition of bile acid synthesis via FXR activation

uk-sce-gastroenterology MCQ (SBA): Primary Biliary Cholangitis

A 55-year-old woman presents with pruritus, steatorrhoea, and osteopenia. AMA is positive at 1:320. ALP is 420 IU/L. She is diagnosed with PBC. What is the mechanism by which UDCA improves cholestasis?