A 48-year-old man on ICU has epilepsy controlled with sodium valproate. He develops severe sepsis requiring IV meropenem. The pharmacist warns of a critical drug interaction. What is the interaction?AMeropenem increases valproate levels causing toxicityBMeropenem reduces valproate levels by up to 60-90% within 24 hours - by inhibiting valproic acid glucuronide hydrolysis in the gut and increasing renal clearance, causing potentially life-threatening breakthrough seizures; this combination should be avoided and an alternative antibiotic or anticonvulsant usedCThere is no interactionDValproate reduces meropenem efficacyEThe interaction only occurs with oral, not IV, meropenemCheck my answer