A 55-year-old man on ICU requires neuromuscular blockade for a surgical procedure. He has myasthenia gravis. What adjustment is needed for non-depolar...

Question

A 55-year-old man on ICU requires neuromuscular blockade for a surgical procedure. He has myasthenia gravis. What adjustment is needed for non-depolarising NMBAs in myasthenia gravis?

Accepted Answer

Patients with MG have increased sensitivity to non-depolarising NMBAs - doses should be reduced to approximately 10-25% of the standard dose and titrated using peripheral nerve stimulation (TOF); the duration of action may be significantly prolonged

Answer

Standard doses are appropriate

Answer

Doses should be doubled

Answer

Non-depolarising NMBAs are contraindicated in MG

Answer

Only suxamethonium can be used in MG

uk-fficm MCQ (SBA): NMBAs in Myasthenia Gravis

A 55-year-old man on ICU requires neuromuscular blockade for a surgical procedure. He has myasthenia gravis. What adjustment is needed for non-depolarising NMBAs in myasthenia gravis?