A 55-year-old man on ICU with severe ARDS has a respiratory system compliance of 12 mL/cmH2O. He is on TV 300 mL (6 mL/kg IBW), PEEP 16, FiO2 1.0, RR 28. Plateau pressure is 41 cmH2O despite the low TV. Driving pressure is 25 cmH2O. PaO2/FiO2 is 55 mmHg. What does this combination of extremely low compliance, high driving pressure despite 6 mL/kg, and refractory hypoxaemia suggest?