A 60-year-old man on ICU is receiving therapeutic anticoagulation with apixaban for atrial fibrillation. He requires emergency craniotomy for a subdural haematoma. Andexanet alfa is not available. What alternative reversal strategy can be used?AIV vitamin KBIV protamine sulphateCIV 4-factor prothrombin complex concentrate (PCC, e.g. Beriplex/Octaplex) 50 IU/kg - PCC provides concentrated clotting factors that can partially overcome the anticoagulant effect of Factor Xa inhibitors, though it does not directly bind or neutralise apixabanDNo reversal is possible - surgery cannot proceedEIV tranexamic acid aloneCheck my answer