A 55-year-old man on ICU has severe sepsis and AKI. He weighs 80 kg. The team initiates CVVHDF. The replacement fluid is administered POST-filter. Wha...

Question

A 55-year-old man on ICU has severe sepsis and AKI. He weighs 80 kg. The team initiates CVVHDF. The replacement fluid is administered POST-filter. What is a potential disadvantage of post-dilution compared to pre-dilution replacement?

Accepted Answer

Post-dilution causes haemoconcentration within the haemofilter (as blood loses water across the membrane without dilution), increasing the risk of filter clotting and reducing filter lifespan

Answer

Post-dilution reduces ultrafiltration clearance

Answer

Post-dilution is always preferable

Answer

Post-dilution reduces drug clearance

Answer

There is no difference between pre and post-dilution

uk-fficm MCQ (SBA): CRRT - Pre vs Post-Dilution

A 55-year-old man on ICU has severe sepsis and AKI. He weighs 80 kg. The team initiates CVVHDF. The replacement fluid is administered POST-filter. What is a potential disadvantage of post-dilution compared to pre-dilution replacement?