A 55-year-old man on ICU develops stress ulcer bleeding with haematemesis. He has been on a PPI for stress ulcer prophylaxis. The team reviews the evi...

Question

A 55-year-old man on ICU develops stress ulcer bleeding with haematemesis. He has been on a PPI for stress ulcer prophylaxis. The team reviews the evidence for stress ulcer prophylaxis (SUP) in ICU. The SUP-ICU trial (2018) examined pantoprazole vs placebo. What was the key finding?

Accepted Answer

Pantoprazole reduced clinically significant GI bleeding but did not reduce mortality, and there were numerically more cases of C. difficile infection and pneumonia in the PPI group

Answer

Pantoprazole significantly reduced mortality

Answer

Pantoprazole was harmful and should never be used

Answer

Pantoprazole eliminated all GI bleeding

Answer

The trial was stopped early for harm

uk-fficm MCQ (SBA): Stress Ulcer Prophylaxis

A 55-year-old man on ICU develops stress ulcer bleeding with haematemesis. He has been on a PPI for stress ulcer prophylaxis. The team reviews the evidence for stress ulcer prophylaxis (SUP) in ICU. The SUP-ICU trial (2018) examined pantoprazole vs placebo. What was the key finding?