A 48-year-old man on ICU has been started on IV vancomycin and IV piperacillin/tazobactam for hospital-acquired sepsis. After 3 days, his creatinine r...

Question

A 48-year-old man on ICU has been started on IV vancomycin and IV piperacillin/tazobactam for hospital-acquired sepsis. After 3 days, his creatinine rises from 90 to 220 µmol/L. Urine output is 35 mL/hr. There is no haemodynamic instability. What is the most likely cause of the AKI?

Accepted Answer

Synergistic nephrotoxicity from the combination of vancomycin and piperacillin/tazobactam - this combination is associated with a significantly higher rate of AKI than either drug alone

Answer

Sepsis-associated AKI

Answer

Contrast nephropathy

Answer

Rhabdomyolysis

Answer

Obstructive uropathy

uk-fficm MCQ (SBA): Drug-Induced AKI

A 48-year-old man on ICU has been started on IV vancomycin and IV piperacillin/tazobactam for hospital-acquired sepsis. After 3 days, his creatinine rises from 90 to 220 µmol/L. Urine output is 35 mL/hr. There is no haemodynamic instability. What is the most likely cause of the AKI?