A 48-year-old woman on ICU develops acute kidney injury requiring CRRT. She is on therapeutic anticoagulation with dabigatran for atrial fibrillation....

Question

A 48-year-old woman on ICU develops acute kidney injury requiring CRRT. She is on therapeutic anticoagulation with dabigatran for atrial fibrillation. Is dabigatran removed by CRRT?

Accepted Answer

Yes - dabigatran has low protein binding (~35%), small molecular weight (472 Da), and is significantly removed by haemodialysis/CRRT

Answer

No - dabigatran is highly protein-bound and not removed

Answer

Dabigatran is only removed by peritoneal dialysis

Answer

CRRT has no effect on any anticoagulant

Answer

Dabigatran is removed but its active metabolites accumulate

uk-fficm MCQ (SBA): Dabigatran and CRRT

A 48-year-old woman on ICU develops acute kidney injury requiring CRRT. She is on therapeutic anticoagulation with dabigatran for atrial fibrillation. Is dabigatran removed by CRRT?