A 60-year-old man on ICU with alcoholic hepatitis has a Maddrey discriminant function (DF) of 42. He has no active GI bleeding, no uncontrolled infect...

Question

A 60-year-old man on ICU with alcoholic hepatitis has a Maddrey discriminant function (DF) of 42. He has no active GI bleeding, no uncontrolled infection, and no renal failure. According to current guidelines, what pharmacological therapy may improve short-term survival?

Accepted Answer

Prednisolone 40 mg OD for 28 days, reassessing at day 7 using the Lille score

Answer

IV N-acetylcysteine only

Answer

Pentoxifylline 400 mg TDS

Answer

IV infliximab

Answer

No pharmacological therapy has been shown to be effective

uk-fficm MCQ (SBA): Severe Alcoholic Hepatitis

A 60-year-old man on ICU with alcoholic hepatitis has a Maddrey discriminant function (DF) of 42. He has no active GI bleeding, no uncontrolled infection, and no renal failure. According to current guidelines, what pharmacological therapy may improve short-term survival?