A 42-year-old woman on ICU is receiving CVVHDF. She is on regular medications including levetiracetam, meropenem, and fluconazole. Which of these drug...

Question

A 42-year-old woman on ICU is receiving CVVHDF. She is on regular medications including levetiracetam, meropenem, and fluconazole. Which of these drugs requires significant dose adjustment due to CRRT removal?

Accepted Answer

Meropenem - it is significantly removed by CRRT due to low protein binding (~2%) and small molecular weight, and the dose should be adjusted or supplemented

Answer

Fluconazole only

Answer

None - CRRT does not affect drug dosing

Answer

Levetiracetam only

Answer

All three drugs are equally affected

uk-fficm MCQ (SBA): Drug Dosing in CRRT

A 42-year-old woman on ICU is receiving CVVHDF. She is on regular medications including levetiracetam, meropenem, and fluconazole. Which of these drugs requires significant dose adjustment due to CRRT removal?