A 48-year-old woman on ICU has acute severe colitis from ulcerative colitis. She has failed 3 days of IV hydrocortisone. Colonoscopy shows deep ulcera...

Question

A 48-year-old woman on ICU has acute severe colitis from ulcerative colitis. She has failed 3 days of IV hydrocortisone. Colonoscopy shows deep ulceration throughout the colon. CRP remains >45, stool frequency >8/day, and she is tachycardic. According to the BSG guidelines, what are the two options at this point?

Accepted Answer

Rescue therapy with IV ciclosporin or infliximab, OR urgent colectomy

Answer

Continue IV hydrocortisone for another 7 days

Answer

Oral 5-ASA and discharge

Answer

Switch to oral prednisolone

Answer

Administer IV immunoglobulin

uk-fficm MCQ (SBA): Acute Severe Ulcerative Colitis