A 65-year-old woman on ICU is receiving a blood transfusion. After 200 mL of the second unit of packed red cells, she develops acute dyspnoea, cough w...

Question

A 65-year-old woman on ICU is receiving a blood transfusion. After 200 mL of the second unit of packed red cells, she develops acute dyspnoea, cough with pink frothy sputum, bilateral crackles, elevated JVP, and hypertension (BP 180/100). SpO2 drops to 88%. CXR shows bilateral pulmonary oedema. BNP is markedly elevated. What is the most likely diagnosis?

Accepted Answer

Transfusion-associated circulatory overload (TACO)

Answer

Transfusion-related acute lung injury (TRALI)

Answer

Acute haemolytic transfusion reaction

Answer

Anaphylactic transfusion reaction

Answer

Bacterial contamination of the blood product

uk-fficm MCQ (SBA): Transfusion-Associated Circulatory Overload