A 52-year-old man on ICU is receiving IV amikacin for a multidrug-resistant Gram-negative infection. A trough level is taken 30 minutes before the nex...

Question

A 52-year-old man on ICU is receiving IV amikacin for a multidrug-resistant Gram-negative infection. A trough level is taken 30 minutes before the next dose and returns at 8 mg/L (target trough

Accepted Answer

Extend the dosing interval to allow the trough to fall below 5 mg/L before the next dose

Answer

Increase the dose - the peak is at the lower end of the target range

Answer

No change needed - both levels are acceptable

Answer

Switch to a different aminoglycoside

Answer

Add vancomycin for synergy

uk-fficm MCQ (SBA): Therapeutic Drug Monitoring

A 52-year-old man on ICU is receiving IV amikacin for a multidrug-resistant Gram-negative infection. A trough level is taken 30 minutes before the next dose and returns at 8 mg/L (target trough <5 mg/L). Peak level post-dose was 28 mg/L (target peak 20-30 mg/L). What adjustment is required?