A 55-year-old man on ICU is being treated with IV dexmedetomidine for sedation. He develops bradycardia (HR 42 bpm) and hypotension (BP 80/50 mmHg). W...

Question

A 55-year-old man on ICU is being treated with IV dexmedetomidine for sedation. He develops bradycardia (HR 42 bpm) and hypotension (BP 80/50 mmHg). What is the mechanism of these haemodynamic effects?

Accepted Answer

Central alpha-2 adrenergic receptor agonism in the locus coeruleus and brainstem, reducing sympathetic outflow

Answer

Beta-2 adrenergic receptor blockade

Answer

Direct myocardial depression via calcium channel blockade

Answer

Histamine release

Answer

Muscarinic receptor antagonism

uk-fficm MCQ (SBA): Dexmedetomidine Pharmacology

A 55-year-old man on ICU is being treated with IV dexmedetomidine for sedation. He develops bradycardia (HR 42 bpm) and hypotension (BP 80/50 mmHg). What is the mechanism of these haemodynamic effects?