A 30-year-old woman is admitted to ICU with a new diagnosis of thrombotic thrombocytopenic purpura (TTP). Her platelet count is 12 × 10⁹/L, Hb 65 g/L ...

Question

A 30-year-old woman is admitted to ICU with a new diagnosis of thrombotic thrombocytopenic purpura (TTP). Her platelet count is 12 × 10⁹/L, Hb 65 g/L with schistocytes on blood film, LDH 2800 U/L, creatinine 180 µmol/L, and she has confusion. ADAMTS13 activity is

Accepted Answer

Urgent therapeutic plasma exchange (TPE) with FFP replacement

Answer

Platelet transfusion to raise the count above 50 × 10⁹/L

Answer

IV immunoglobulin 0.4 g/kg/day for 5 days

Answer

IV cyclophosphamide

Answer

Splenectomy

uk-fficm MCQ (SBA): Thrombotic Thrombocytopenic Purpura