A 55-year-old man on ICU following cardiac surgery develops a seizure. He is receiving a continuous IV infusion of tramadol for pain and was recently ...

Question

A 55-year-old man on ICU following cardiac surgery develops a seizure. He is receiving a continuous IV infusion of tramadol for pain and was recently started on IV ondansetron for nausea. His previous medications include sertraline. What is the most likely drug-related cause of the seizure?

Accepted Answer

Tramadol-induced seizure, potentially exacerbated by serotonergic interaction with sertraline

Answer

Ondansetron-induced QT prolongation causing a cardiac arrhythmia mimicking seizure

Answer

Sertraline withdrawal seizure

Answer

Propofol-related seizure activity

Answer

Hyponatraemia from ondansetron

uk-fficm MCQ (SBA): Drug-Induced Seizure

A 55-year-old man on ICU following cardiac surgery develops a seizure. He is receiving a continuous IV infusion of tramadol for pain and was recently started on IV ondansetron for nausea. His previous medications include sertraline. What is the most likely drug-related cause of the seizure?