A 65-year-old woman on ICU has sepsis-associated AKI requiring CVVHDF. She was on regular oral medications including phenytoin 300 mg daily, atorvasta...

Question

A 65-year-old woman on ICU has sepsis-associated AKI requiring CVVHDF. She was on regular oral medications including phenytoin 300 mg daily, atorvastatin 40 mg daily, and amlodipine 10 mg daily. Which of these medications requires dose adjustment or particular monitoring during CRRT?

Accepted Answer

Phenytoin - serum levels should be monitored closely as CRRT can alter free drug levels in the context of hypoalbuminaemia and critical illness

Answer

Atorvastatin

Answer

Amlodipine

Answer

All medications are completely removed by CRRT and should be doubled

Answer

None of these medications are affected by CRRT

uk-fficm MCQ (SBA): Drug Dosing in CRRT

A 65-year-old woman on ICU has sepsis-associated AKI requiring CVVHDF. She was on regular oral medications including phenytoin 300 mg daily, atorvastatin 40 mg daily, and amlodipine 10 mg daily. Which of these medications requires dose adjustment or particular monitoring during CRRT?