A 70-year-old woman on warfarin for atrial fibrillation is admitted to ICU with a large intracerebral haemorrhage. Her INR is 4.8. According to BSH gu...

Question

A 70-year-old woman on warfarin for atrial fibrillation is admitted to ICU with a large intracerebral haemorrhage. Her INR is 4.8. According to BSH guidelines, what is the most appropriate immediate reversal strategy?

Accepted Answer

IV prothrombin complex concentrate (PCC, e.g. Beriplex/Octaplex) 25-50 IU/kg and IV vitamin K 5 mg

Answer

IV vitamin K 5 mg alone

Answer

Fresh frozen plasma 15 mL/kg

Answer

Recombinant Factor VIIa (rFVIIa) 90 mcg/kg

Answer

Withhold warfarin and wait for INR to normalise spontaneously

uk-fficm MCQ (SBA): Warfarin Reversal

A 70-year-old woman on warfarin for atrial fibrillation is admitted to ICU with a large intracerebral haemorrhage. Her INR is 4.8. According to BSH guidelines, what is the most appropriate immediate reversal strategy?