A 45-year-old man on ICU requires continuous sedation. He has acute liver failure with an INR of 5.2 and bilirubin 480 µmol/L. Which sedative agent is most suitable in the context of severe hepatic impairment?APropofol - as it undergoes hepatic conjugation and will accumulate dangerouslyBIV midazolam - as benzodiazepines are safe in liver failureCPropofol - as although hepatically metabolised, it has additional extrahepatic clearance mechanisms and a relatively predictable pharmacokinetic profile even in liver failureDIV diazepam - as it has a short half-lifeEOral chlordiazepoxideCheck my answer