A 55-year-old man on ICU requires rocuronium for emergency intubation. He has KDIGO Stage 3 AKI with anuria and is not yet on RRT. What is the expecte...

Question

A 55-year-old man on ICU requires rocuronium for emergency intubation. He has KDIGO Stage 3 AKI with anuria and is not yet on RRT. What is the expected effect of renal failure on the duration of action of rocuronium?

Accepted Answer

Significantly prolonged duration of action

Answer

No change - rocuronium is entirely hepatically metabolised

Answer

Shortened duration of action

Answer

Complete inability to metabolise the drug - it will never wear off

Answer

Duration unchanged but onset will be delayed

uk-fficm MCQ (SBA): Renal Pharmacokinetics

A 55-year-old man on ICU requires rocuronium for emergency intubation. He has KDIGO Stage 3 AKI with anuria and is not yet on RRT. What is the expected effect of renal failure on the duration of action of rocuronium?