A 48-year-old woman on ICU develops tumour lysis syndrome following chemotherapy for acute lymphoblastic leukaemia. Laboratory results: potassium 6.5 ...

Question

A 48-year-old woman on ICU develops tumour lysis syndrome following chemotherapy for acute lymphoblastic leukaemia. Laboratory results: potassium 6.5 mmol/L, phosphate 3.8 mmol/L, uric acid 850 µmol/L, calcium 1.65 mmol/L, creatinine 320 µmol/L. Which specific pharmacological agent is indicated for the hyperuricaemia?

Accepted Answer

Rasburicase 0.2 mg/kg IV

Answer

Allopurinol 300 mg daily

Answer

Febuxostat 80 mg daily

Answer

Colchicine 500 mcg BD

Answer

Probenecid 500 mg BD

uk-fficm MCQ (SBA): Tumour Lysis Syndrome