A 58-year-old woman on ICU develops septic shock from an infected pancreatic pseudocyst. She has been on broad-spectrum antibiotics for 18 days. New b...

Question

A 58-year-old woman on ICU develops septic shock from an infected pancreatic pseudocyst. She has been on broad-spectrum antibiotics for 18 days. New blood cultures grow Candida glabrata. The microbiology report notes that the isolate has reduced susceptibility to fluconazole (MIC 32 mg/L). What is the most appropriate antifungal?

Accepted Answer

IV caspofungin 70 mg loading dose then 50 mg daily

Answer

Oral fluconazole 400 mg daily

Answer

IV fluconazole 800 mg daily (high-dose)

Answer

IV amphotericin B deoxycholate 1 mg/kg daily

Answer

IV voriconazole 6 mg/kg BD loading then 4 mg/kg BD

uk-fficm MCQ (SBA): Invasive Candidiasis