A 42-year-old man returns from a holiday in Southeast Asia with a 5-day history of fever, rigors, and confusion. He is admitted to ICU with GCS 10, te...

Question

A 42-year-old man returns from a holiday in Southeast Asia with a 5-day history of fever, rigors, and confusion. He is admitted to ICU with GCS 10, temperature 40°C, and a blood film showing Plasmodium falciparum parasitaemia of 8%. Creatinine is 280 µmol/L, bilirubin 95 µmol/L, Hb 78 g/L, platelets 42 × 10⁹/L. What is the first-line treatment?

Accepted Answer

IV artesunate

Answer

Oral chloroquine

Answer

IV quinine with oral doxycycline

Answer

Oral atovaquone-proguanil (Malarone)

Answer

IV clindamycin monotherapy

uk-fficm MCQ (SBA): Severe Falciparum Malaria