A 50-year-old man is admitted to ICU with necrotising fasciitis of the right lower limb. He is in septic shock (noradrenaline 0.5 mcg/kg/min, lactate ...

Question

A 50-year-old man is admitted to ICU with necrotising fasciitis of the right lower limb. He is in septic shock (noradrenaline 0.5 mcg/kg/min, lactate 9.0 mmol/L). Blood cultures grow Group A Streptococcus (S. pyogenes). In addition to broad-spectrum antibiotics, which specific antibiotic should be added to the regimen?

Accepted Answer

IV clindamycin to inhibit toxin production

Answer

IV metronidazole for anaerobic cover

Answer

IV gentamicin for synergistic bactericidal activity

Answer

IV fluconazole for fungal co-infection

Answer

IV rifampicin for biofilm penetration

uk-fficm MCQ (SBA): Necrotising Fasciitis