A 35-year-old woman on ICU has developed serotonin syndrome. She was started on linezolid 3 days ago for MRSA pneumonia, and is also receiving a fenta...

Question

A 35-year-old woman on ICU has developed serotonin syndrome. She was started on linezolid 3 days ago for MRSA pneumonia, and is also receiving a fentanyl infusion and was recently commenced on oral fluoxetine for depression. Which combination is most likely responsible for the serotonin syndrome?

Accepted Answer

Linezolid and fluoxetine

Answer

Fentanyl and fluoxetine

Answer

Fentanyl and linezolid

Answer

All three agents acting synergistically

Answer

Fluoxetine alone at standard dose

uk-fficm MCQ (SBA): Serotonin Syndrome

A 35-year-old woman on ICU has developed serotonin syndrome. She was started on linezolid 3 days ago for MRSA pneumonia, and is also receiving a fentanyl infusion and was recently commenced on oral fluoxetine for depression. Which combination is most likely responsible for the serotonin syndrome?