A 70-year-old man on ICU with AKI (creatinine 450 µmol/L, eGFR 10 mL/min) requires empirical antibiotic therapy for suspected hospital-acquired pneumo...

Question

A 70-year-old man on ICU with AKI (creatinine 450 µmol/L, eGFR 10 mL/min) requires empirical antibiotic therapy for suspected hospital-acquired pneumonia. The microbiologist recommends piperacillin/tazobactam. What dose adjustment is required?

Accepted Answer

Extend the dosing interval to 4.5 g BD (12-hourly)

Answer

No dose adjustment is required

Answer

Reduce the dose to 2.25 g TDS

Answer

Reduce the dose to 2.25 g BD

Answer

Give a loading dose of 4.5 g then switch to a continuous infusion at reduced rate

uk-fficm MCQ (SBA): Renal Dose Adjustment

A 70-year-old man on ICU with AKI (creatinine 450 µmol/L, eGFR 10 mL/min) requires empirical antibiotic therapy for suspected hospital-acquired pneumonia. The microbiologist recommends piperacillin/tazobactam. What dose adjustment is required?