A 45-year-old woman on ICU is being treated for a severe hospital-acquired MRSA pneumonia with IV vancomycin. A pre-dose (trough) vancomycin level ret...

Question

A 45-year-old woman on ICU is being treated for a severe hospital-acquired MRSA pneumonia with IV vancomycin. A pre-dose (trough) vancomycin level returns at 8 mg/L (target trough 15-20 mg/L for serious MRSA infections). What is the most appropriate action?

Accepted Answer

Increase the dose of vancomycin and recheck the trough level before the next dose

Answer

Continue the same dose as the level is within an acceptable range

Answer

Switch to oral vancomycin

Answer

Add rifampicin to the current vancomycin regimen

Answer

Discontinue vancomycin and switch to teicoplanin

uk-fficm MCQ (SBA): Therapeutic Drug Monitoring

A 45-year-old woman on ICU is being treated for a severe hospital-acquired MRSA pneumonia with IV vancomycin. A pre-dose (trough) vancomycin level returns at 8 mg/L (target trough 15-20 mg/L for serious MRSA infections). What is the most appropriate action?