A 70-year-old man on ICU is receiving a propofol infusion at 4 mg/kg/hr for 5 days following neurosurgery. He develops an unexplained metabolic acidos...

Question

A 70-year-old man on ICU is receiving a propofol infusion at 4 mg/kg/hr for 5 days following neurosurgery. He develops an unexplained metabolic acidosis (pH 7.18, lactate 8 mmol/L), rhabdomyolysis (CK 45,000 U/L), acute kidney injury, and a new Brugada-like ECG pattern. What is the most likely diagnosis?

Accepted Answer

Propofol infusion syndrome (PRIS)

Answer

Malignant hyperthermia

Answer

Neuroleptic malignant syndrome

Answer

Serotonin syndrome

Answer

Septic shock with multi-organ failure

uk-fficm MCQ (SBA): Propofol Infusion Syndrome