A 55-year-old woman with septic shock from necrotising pancreatitis has been on ICU for 21 days. She has received piperacillin/tazobactam, then merope...

Question

A 55-year-old woman with septic shock from necrotising pancreatitis has been on ICU for 21 days. She has received piperacillin/tazobactam, then meropenem. She has had multiple CT-guided drains. Her latest wound swab grows Pseudomonas aeruginosa resistant to meropenem but sensitive to colistin and ceftazidime/avibactam. What is the most appropriate antibiotic strategy?

Accepted Answer

Switch to ceftazidime/avibactam with consideration of combination therapy

Answer

Continue meropenem at double dose (2g TDS)

Answer

Switch to IV colistin as monotherapy

Answer

Add IV gentamicin to meropenem

Answer

Switch to oral ciprofloxacin

uk-fficm MCQ (SBA): Multi-Drug Resistant Infection