A 78-year-old man with depression, chronic pain, and COPD is on Duloxetine 60 mg and Tramadol 50 mg QDS. He becomes agitated, sweaty, tremulous with d...

Question

A 78-year-old man with depression, chronic pain, and COPD is on Duloxetine 60 mg and Tramadol 50 mg QDS. He becomes agitated, sweaty, tremulous with dilated pupils. What drug safety concern should be considered?

Accepted Answer

Serotonin syndrome - both Duloxetine and Tramadol are serotonergic, carrying significant combined risk

Answer

Normal Duloxetine side effects

Answer

Panic attack

Answer

COPD exacerbation symptoms

Answer

Duloxetine allergy

uk-dgm MCQ (SBA): Serotonin Syndrome - Duloxetine and Tramadol

A 78-year-old man with depression, chronic pain, and COPD is on Duloxetine 60 mg and Tramadol 50 mg QDS. He becomes agitated, sweaty, tremulous with dilated pupils. What drug safety concern should be considered?