A 74-year-old woman with osteoporosis has been on Denosumab 60 mg subcutaneously every 6 months for 3 years. She wants to stop the medication due to i...

Question

A 74-year-old woman with osteoporosis has been on Denosumab 60 mg subcutaneously every 6 months for 3 years. She wants to stop the medication due to injection site reactions. What is the MOST important advice regarding Denosumab discontinuation?

Accepted Answer

Stopping Denosumab can cause rapid bone loss (rebound effect) with increased risk of multiple vertebral fractures - transition to an alternative bone protection agent (e.g., bisphosphonate) before or at the time of Denosumab discontinuation is essential

Answer

She can stop Denosumab at any time with no consequences

Answer

Denosumab has no rebound effect

Answer

She should stop Denosumab and take calcium supplements only

Answer

Denosumab effects persist for years after stopping

uk-dgm MCQ (SBA): Denosumab Discontinuation - Rebound Fracture Risk

A 74-year-old woman with osteoporosis has been on Denosumab 60 mg subcutaneously every 6 months for 3 years. She wants to stop the medication due to injection site reactions. What is the MOST important advice regarding Denosumab discontinuation?