A 72-year-old woman with CKD stage 4 (eGFR 22) and chronic pain is prescribed Gabapentin 300 mg TDS by her GP. She develops increasing drowsiness, diz...

Question

A 72-year-old woman with CKD stage 4 (eGFR 22) and chronic pain is prescribed Gabapentin 300 mg TDS by her GP. She develops increasing drowsiness, dizziness, and unsteadiness over 2 weeks. What is the MOST likely cause?

Accepted Answer

Gabapentin accumulation due to reduced renal clearance at this eGFR - the dose needs significant reduction

Answer

Gabapentin is not effective for pain and she needs a stronger opioid

Answer

She has developed a new neurological condition

Answer

Gabapentin allergy

Answer

Drug interaction with her antihypertensive

uk-dgm MCQ (SBA): Gabapentin Accumulation in CKD

A 72-year-old woman with CKD stage 4 (eGFR 22) and chronic pain is prescribed Gabapentin 300 mg TDS by her GP. She develops increasing drowsiness, dizziness, and unsteadiness over 2 weeks. What is the MOST likely cause?