A 75-year-old man has a history of recurrent gout attacks and chronic tophaceous gout. He has CKD stage 3b (eGFR 32 mL/min/1.73m²). He is commenced on...

Question

A 75-year-old man has a history of recurrent gout attacks and chronic tophaceous gout. He has CKD stage 3b (eGFR 32 mL/min/1.73m²). He is commenced on Allopurinol for urate-lowering therapy. According to best practice, at what dose should Allopurinol be STARTED in this patient?

Accepted Answer

50 mg daily or even 50 mg on alternate days, with slow uptitration guided by serum urate levels and renal function

Answer

300 mg daily

Answer

100 mg daily as standard starting dose for all patients

Answer

600 mg daily to achieve rapid urate lowering

Answer

200 mg daily

uk-dgm MCQ (SBA): Allopurinol Starting Dose in CKD

A 75-year-old man has a history of recurrent gout attacks and chronic tophaceous gout. He has CKD stage 3b (eGFR 32 mL/min/1.73m²). He is commenced on Allopurinol for urate-lowering therapy. According to best practice, at what dose should Allopurinol be STARTED in this patient?