A 73-year-old man with mild frailty (CFS 4) has chronic stable angina, type 2 diabetes, and mild CKD (eGFR 52). He takes Aspirin 75 mg, Atorvastatin 4...

Question

A 73-year-old man with mild frailty (CFS 4) has chronic stable angina, type 2 diabetes, and mild CKD (eGFR 52). He takes Aspirin 75 mg, Atorvastatin 40 mg, Bisoprolol 5 mg, GTN spray PRN, Metformin 1 g BD, and Omeprazole 20 mg daily. He has no history of peptic ulcer disease or GORD. His Omeprazole was started 3 years ago for 'indigestion' that resolved after 2 weeks. According to STOPP criteria, what action should be taken?

Accepted Answer

Step down Omeprazole to a lower dose and then attempt discontinuation, as there is no ongoing indication for PPI therapy

Answer

Continue Omeprazole indefinitely as it provides gastroprotection with Aspirin

Answer

Increase Omeprazole to 40 mg for better effect

Answer

Switch to Ranitidine instead

Answer

Add Sucralfate for additional protection

uk-dgm MCQ (SBA): PPI Step-Down and Discontinuation