An 86-year-old man with a CFS of 6, type 2 diabetes, and CKD stage 3b (eGFR 36) has been on Metformin 1 g BD and Sitagliptin 100 mg OD. His most recen...

Question

An 86-year-old man with a CFS of 6, type 2 diabetes, and CKD stage 3b (eGFR 36) has been on Metformin 1 g BD and Sitagliptin 100 mg OD. His most recent blood tests show eGFR 36 and HbA1c 52 mmol/mol. What medication adjustment is required?

Accepted Answer

Reduce Sitagliptin to 50 mg daily due to renal impairment

Answer

Continue both at current doses as HbA1c is at target

Answer

Stop Metformin immediately

Answer

Increase Metformin to 2 g BD to further lower HbA1c

Answer

Add Gliclazide to intensify therapy

uk-dgm MCQ (SBA): Sitagliptin Renal Dose Adjustment

An 86-year-old man with a CFS of 6, type 2 diabetes, and CKD stage 3b (eGFR 36) has been on Metformin 1 g BD and Sitagliptin 100 mg OD. His most recent blood tests show eGFR 36 and HbA1c 52 mmol/mol. What medication adjustment is required?