A 86-year-old man with CKD stage 4 (eGFR 18 mL/min/1.73m²) is prescribed Codeine 30 mg QDS for back pain. He develops drowsiness, confusion, and pinpo...

Question

A 86-year-old man with CKD stage 4 (eGFR 18 mL/min/1.73m²) is prescribed Codeine 30 mg QDS for back pain. He develops drowsiness, confusion, and pinpoint pupils. What is the MOST likely cause of his symptoms?

Accepted Answer

Accumulation of active Codeine metabolites due to impaired renal clearance

Answer

Codeine overdose from intentional self-harm

Answer

A new diagnosis of dementia

Answer

Cerebrovascular accident

Answer

Sepsis

uk-dgm MCQ (SBA): Opioid Accumulation in Renal Impairment

A 86-year-old man with CKD stage 4 (eGFR 18 mL/min/1.73m²) is prescribed Codeine 30 mg QDS for back pain. He develops drowsiness, confusion, and pinpoint pupils. What is the MOST likely cause of his symptoms?