A 72-year-old man has been taking Digoxin 125 micrograms daily for rate control in atrial fibrillation. His eGFR has declined from 58 to 28 mL/min/1.7...

Question

A 72-year-old man has been taking Digoxin 125 micrograms daily for rate control in atrial fibrillation. His eGFR has declined from 58 to 28 mL/min/1.73m² over 6 months. He presents with nausea, blurred vision, and a heart rate of 48 bpm. His Digoxin level is 3.1 nmol/L (therapeutic range 1.0-2.0). What is the MOST likely explanation?

Accepted Answer

Reduced renal clearance of Digoxin due to declining eGFR, causing accumulation and toxicity

Answer

Digoxin overdose from intentional self-harm

Answer

A new drug interaction with a CYP3A4 inhibitor

Answer

Digoxin allergy

Answer

Normal Digoxin levels in older people

uk-dgm MCQ (SBA): Digoxin Toxicity in Renal Impairment