A 77-year-old woman with Parkinson's disease is admitted to hospital. The junior doctor prescribes Prochlorperazine for nausea. The ward pharmacist fl...

Question

A 77-year-old woman with Parkinson's disease is admitted to hospital. The junior doctor prescribes Prochlorperazine for nausea. The ward pharmacist flags this prescription. Why is Prochlorperazine contraindicated in Parkinson's disease?

Accepted Answer

It is a dopamine receptor antagonist that worsens Parkinsonian symptoms and may precipitate a crisis

Answer

It is a potent anticholinergic that worsens constipation

Answer

It interacts with Levodopa to cause serotonin syndrome

Answer

It causes severe hypoglycaemia in combination with Levodopa

Answer

It is hepatotoxic in Parkinson's disease patients

uk-dgm MCQ (SBA): Dopamine Antagonist Avoidance in PD

A 77-year-old woman with Parkinson's disease is admitted to hospital. The junior doctor prescribes Prochlorperazine for nausea. The ward pharmacist flags this prescription. Why is Prochlorperazine contraindicated in Parkinson's disease?