A 80-year-old woman is admitted to the acute medical unit with a 2-day history of lower abdominal pain and confusion. She has a history of recurrent U...

Question

A 80-year-old woman is admitted to the acute medical unit with a 2-day history of lower abdominal pain and confusion. She has a history of recurrent UTIs and takes prophylactic Nitrofurantoin 50 mg at night. Her eGFR is 42 mL/min/1.73m². Urine dipstick shows leucocytes ++ and nitrites +. According to STOPP criteria, what prescribing concern should be raised?

Accepted Answer

Nitrofurantoin is inappropriate when eGFR is below 45 mL/min/1.73m²

Answer

Prophylactic antibiotics should never be used for recurrent UTIs

Answer

Nitrofurantoin should be switched to Trimethoprim for prophylaxis

Answer

Nitrofurantoin causes hepatotoxicity in all patients over 75

Answer

Nitrofurantoin is only effective against Gram-positive organisms

uk-dgm MCQ (SBA): Nitrofurantoin in CKD - STOPP Criteria