uk-dgm MCQ (SBA): SSRI-Induced SIADH and Hyponatraemia

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HardPolypharmacy & PrescribingSSRI-Induced SIADH and Hyponatraemiauk-dgm

A 82-year-old man is admitted from a care home with reduced oral intake, drowsiness, and a serum sodium of 118 mmol/L. His medications include Sertraline 100 mg, Omeprazole 20 mg, Bendroflumethiazide 2.5 mg, and Amlodipine 5 mg. Paired serum and urine osmolality suggest SIADH (serum osmolality 260 mOsm/kg, urine osmolality 450 mOsm/kg). Which medication is the MOST likely cause?

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uk-dgm MCQ: SSRI-Induced SIADH and Hyponatraemia — Answer & Explanatio