A 79-year-old woman with Alzheimer's disease is currently taking Donepezil 10 mg daily. Her MMSE has declined from 18 to 12 over the past 12 months. S...

Question

A 79-year-old woman with Alzheimer's disease is currently taking Donepezil 10 mg daily. Her MMSE has declined from 18 to 12 over the past 12 months. She is becoming increasingly dependent and her carer is struggling. According to NICE NG97, what is the MOST appropriate medication change?

Accepted Answer

Add Memantine to Donepezil

Answer

Stop Donepezil and start Memantine

Answer

Increase Donepezil and add Rivastigmine

Answer

Stop Donepezil as it is no longer effective

Answer

Continue Donepezil alone with no change

uk-dgm MCQ (SBA): Adding Memantine in Moderate Alzheimer's Disease

A 79-year-old woman with Alzheimer's disease is currently taking Donepezil 10 mg daily. Her MMSE has declined from 18 to 12 over the past 12 months. She is becoming increasingly dependent and her carer is struggling. According to NICE NG97, what is the MOST appropriate medication change?