A patient on isoniazid develops peripheral neuropathy despite pyridoxine. He is a slow acetylator. What does this mean?...

Question

A patient on isoniazid develops peripheral neuropathy despite pyridoxine. He is a slow acetylator. What does this mean?

Accepted Answer

Slow NAT2 acetylation reduces isoniazid clearance, increasing plasma levels and risk of dose-dependent neuropathy and hepatotoxicity

Answer

He metabolises isoniazid rapidly

Answer

Slow acetylator status is protective

Answer

Acetylator status has no relevance

Answer

Only fast acetylators develop neuropathy

uk-dtmh MCQ (SBA): NAT2 Slow Acetylator Isoniazid