A 50-year-old woman from Cameroon has chronic onchocerciasis despite 10 years of annual ivermectin. What is the key limitation of ivermectin?...

Question

A 50-year-old woman from Cameroon has chronic onchocerciasis despite 10 years of annual ivermectin. What is the key limitation of ivermectin?

Accepted Answer

It is a potent microfilaricide but has limited macrofilaricidal activity; adult worms survive and resume microfilaria production, requiring indefinite repeated treatment

Answer

It has no activity against O. volvulus

Answer

It kills adult worms permanently after one dose

Answer

It only works against Loa loa

Answer

Resistance has not been reported

uk-dtmh MCQ (SBA): Ivermectin Limitation in Onchocerciasis

A 50-year-old woman from Cameroon has chronic onchocerciasis despite 10 years of annual ivermectin. What is the key limitation of ivermectin?